Direct-to-consumer advertising of healthcare products refers to a variety of marketing practices based on a combination of information and promotion strategies directed at consumers through different media such as radio and television broadcasts, newspaper and magazine ads, and, more recently, through the Internet. The principal form of marketing used by the pharmaceutical industry is the distribution of free samples to physicians but DTCA is an increasing part of global promotional spending for prescription drugs. Latest estimates suggest that DTCA now represents (...) an annual $3.2 billion enterprise for the U.S. pharmaceutical industry. Findings from the literature show that these substantial efforts are geared toward the newer pharmaceuticals for chronic conditions with huge market potentials. The lion's share is going to the 20 most prescribed pharmaceuticals. (shrink)

This commentary discusses three main requirements for models of vision, namely, translation and scale invariance, scalability, and hierarchy. Edelman's Chorus model falls short of fulfilling these requirements because it ignores the highly dynamic nature of vision. Incorporating an attentional mechanism and assuming geon-like prototype representations may enhance Chorus's plausibility as a model of human object recognition.

This article aims to initiate a discussion on the demarcation of the ethics of care. This discussion is necessary because the ethics of care evolves by making use of insights from varying disciplines. As this involves the risk of contamination of the care ethical discipline, the challenge for care ethical scholars is to ensure to retain a distinct care ethical perspective. This may be supported by an open and critical debate on the criteria and boundaries of the ethics of care. (...) As a contribution, this article proposes a tentative outline of the care ethical discipline. What is characteristic of this outline is the emphasis on relational programming, situation-specific and context-bound judgments, a political–ethical perspective, and empirical groundedness. It is argued that the ethics of care is best developed further by means of an intradisciplinary approach. Two intradisciplinary examples show how within the frame of one discipline, other disciplines are absorbed, both with their body of knowledge and their research methodology. (shrink)

In the current paper we present an instrumental approach to deception. This approach incorporates the notion that bargainers (a) will use deception as a means to reach their goals in bargaining but (b) will refrain from using deception when they have alternative means to reach their goals. We demonstrate that different goals can lead to differences in the use of deception (Experiment 1). Furthermore, we demonstrate that reactions to deceit can also be understood from an instrumental perspective (Experiment 2).

Enthusiasm is a relatively under-explored emotion. The current research explores the unique characteristics of enthusiasm by examining its cognitive appraisals (Study 1, N = 300) and response types (Study 2, N = 298) and comparing it with joy and hope. Participants in both studies recalled and rated events where they felt enthusiasm, joy, or hope. Study 1 revealed that enthusiasm occurs in pleasurable, intense situations linked to desired goals. More than joy, it is driven by goal-achievement anticipation. Compared to hope, (...) enthusiasm is associated with more control, less uncertainty, and immediate relevance. Study 2 defines enthusiasm as a positive, energetic state marked by smiling, presence, fulfilment, and thoughts of positive outcomes. Compared to joy, it incites more eagerness, risk willingness, and inclination to join a movement. More than hope, it triggers immediate action without contemplation of negative outcomes. We conclude that enthusiasm is a positive, energetic condition often triggered by pleasurable, intense situations aligning with desired goals. It differs from joy and hope. Enthusiasm drives action when goals are attainable, and risks will likely pay off. Hope emerges when a goal is uncertain and distant. Joy typically follows goal accomplishment and is associated with feelings of connection and a desire to savour the moment. (shrink)

During the course of evolution, variations of a protein sequence is an ongoing phenomenon however limited by the need to maintain its structural and functional integrity. Deciphering the evolutionary path of a protein is thus of fundamental interest. With the development of new methods to visualize high dimension spaces and the improvement of phylogenetic analysis tools, it is possible to study the evolutionary trajectories of proteins in the sequence space. Using the data-driven high-dimensional scaling method, we show that it is (...) possible to predict and represent potential evolutionary trajectories by representing phylogenetic trees into a 3D projection of the sequence space. With the case of the aminodeoxychorismate synthase, an enzyme involved in folate synthesis, we show that this representation raises interesting questions about the complexity of the evolution of a given biological function, in particular concerning its capacity to explore the sequence space. (shrink)

A variety of logical frameworks have been developed to study rational agents interacting over time. This paper takes a closer look at one particular interface, between two systems that both address the dynamics of knowledge and information flow. The first is Epistemic Temporal Logic (ETL) which uses linear or branching time models with added epistemic structure induced by agents’ different capabilities for observing events. The second framework is Dynamic Epistemic Logic (DEL) that describes interactive processes in terms of epistemic event (...) models which may occur inside modalities of the language. This paper systematically and rigorously relates the DEL framework with the ETL framework. The precise relationship between DEL and ETL is explored via a new representation theorem characterizing the largest class of ETL models corresponding to DEL protocols in terms of notions of Perfect Recall , No Miracles , and Bisimulation Invariance . We then focus on new issues of completeness . One contribution is an axiomatization for the dynamic logic of public announcements constrained by protocols, which has been an open problem for some years, as it does not fit the usual ‘reduction axiom’ format of DEL. Finally, we provide a number of examples that show how DEL suggests an interesting fine-structure inside ETL. (shrink)

Replicating or exceeding human intelligence, not just in particular domains but in general, has always been a major goal of Artificial Intelligence (AI). We argue here that “human intelligence” is not only ill-defined, but often conflated with broader aspects of human psychology. Standard arguments for replicating it are morally unacceptable. We then suggest a reframing: that the proper goal of AI is not to replicate humans, but to complement them by creating diverse intelligences capable of collaborating with humans. This goal (...) renders issues of theory of mind, empathy, and caring, or community engagement, central to AI. It also challenges AI to better understand the circumstances in which human intelligence, including human moral intelligence, fails. (shrink)

The suggestion of seeking specificity in a higher-order array is attractive, but Stoffregen & Bardy fail to provide a compelling empirical basis to their claim that specificity exists solely in the global array. Using the example of relative motion, the alternate hypotheses that must be considered are presented.

The intuitive notion of evidence has both semantic and syntactic features. In this paper, we develop an evidence logic for epistemic agents faced with possibly contradictory evidence from different sources. The logic is based on a neighborhood semantics, where a neighborhood N indicates that the agent has reason to believe that the true state of the world lies in N. Further notions of relative plausibility between worlds and beliefs based on the latter ordering are then defined in terms of this (...) evidence structure, yielding our intended models for evidence-based beliefs. In addition, we also consider a second more general flavor, where belief and plausibility are modeled using additional primitive relations, and we prove a representation theorem showing that each such general model is a p-morphic image of an intended one. This semantics invites a number of natural special cases, depending on how uniform we make the evidence sets, and how coherent their total structure. We give a structural study of the resulting ‘uniform’ and ‘flat’ models. Our main result are sound and complete axiomatizations for the logics of all four major model classes with respect to the modal language of evidence, belief and safe belief. We conclude with an outlook toward logics for the dynamics of changing evidence, and the resulting language extensions and connections with logics of plausibility change. (shrink)

This paper adds evidence structure to standard models of belief, in the form of families of sets of worlds. We show how these more fine-grained models support natural actions of “evidence management”, ranging from update with external new information to internal rearrangement. We show how this perspective leads to new richer languages for existing neighborhood semantics for modal logic. Our main results are relative completeness theorems for the resulting dynamic logic of evidence.

The combination of logic and game theory provides a fine-grained perspective on information and interaction dynamics, a Theory of Play. In this paper we lay down the main components of such a theory, drawing on recent advances in the logical dynamics of actions, preferences, and information. We then show how this fine-grained perspective has already shed new light on the long-term dynamics of information exchange, as well as on the much-discussed question of extensive game rationality.

Wynes and Nicholas (2017) argue that the most effective action to reduce individual greenhouse gas (GHG) emissions is to have one fewer child. We raise methodological concerns about the way in which the authors attribute responsibility for emissions: they rely on multiple counting when calculating the emissions of future generations, and they exclude scenarios in which global emission trajectories become net-zero or negative. This may distort recommendations from policy makers and educators who rely on their study. We propose an alternative (...) way of attributing responsibility that avoids multiple counting. Investigating the implications of having children under this proposal with regards to the full range of different scenarios, including likelihood analyses, calls for further studies. (shrink)

Most models of response time (RT) in elementary cognitive tasks implicitly assume that the speed-accuracy trade-off is continuous: When payoffs or instructions gradually increase the level of speed stress, people are assumed to gradually sacrifice response accuracy in exchange for gradual increases in response speed. This trade-off presumably operates over the entire range from accurate but slow responding to fast but chance-level responding (i.e., guessing). In this article, we challenge the assumption of continuity and propose a phase transition model for (...) RTs and accuracy. Analogous to the fast guess model (Ollman, 1966), our model postulates two modes of processing: a guess mode and a stimulus-controlled mode. From catastrophe theory, we derive two important predictions that allow us to test our model against the fast guess model and against the popular class of sequential sampling models. The first prediction—hysteresis in the transitions between guessing and stimulus-controlled behavior—was confirmed in an experiment that gradually changed the reward for speed versus accuracy. The second prediction—bimodal RT distributions—was confirmed in an experiment that required participants to respond in a way that is intermediate between guessing and accurate responding. (shrink)

Patients with a life-threatening illness can be confronted with various types of loneliness, one of which is existential loneliness (EL). Since the experience of EL is extremely disruptive, the issue of EL is relevant for the practice of end-of-life care. Still, the literature on EL has generated little discussion and empirical substantiation and has never been systematically reviewed. In order to systematically review the literature, we (1) identified the existential loneliness literature; (2) established an organising framework for the review; (3) (...) conducted a conceptual analysis of existential loneliness; and (4) discussed its relevance for end-of-life care. We found that the EL concept is profoundly unclear. Distinguishing between three dimensions of EL—as a condition, as an experience, and as a process of inner growth—leads to some conceptual clarification. Analysis of these dimensions on the basis of their respective key notions—everpresent, feeling, defence; death, awareness, difficult communication; and inner growth, giving meaning, authenticity—further clarifies the concept. Although none of the key notions are unambiguous, they may function as a starting point for the development of care strategies on EL at the end of life. (shrink)

After more than 15 years of study, the 1/f noise or complex-systems approach to cognitive science has delivered promises of progress, colorful verbiage, and statistical analyses of phenomena whose relevance for cognition remains unclear. What the complex-systems approach has arguably failed to deliver are concrete insights about how people perceive, think, decide, and act. Without formal models that implement the proposed abstract concepts, the complex-systems approach to cognitive science runs the danger of becoming a philosophical exercise in futility. The complex-systems (...) approach can be informative and innovative, but only if it is implemented as a formal model that allows concrete prediction, falsification, and comparison against more traditional approaches. (shrink)

Theoretical arguments and empirical investigations indicate that a high proportion of published findings do not replicate and are likely false. The current position paper provides a broad perspective on scientific error, which may lead to replication failures. This broad perspective focuses on reform history and on opportunities for future reform. We organize our perspective along four main themes: institutional reform, methodological reform, statistical reform and publishing reform. For each theme, we illustrate potential errors by narrating the story of a fictional (...) researcher during the research cycle. We discuss future opportunities for reform. The resulting agenda provides a resource to usher in an era that is marked by a research culture that is less error-prone and a scientific publication landscape with fewer spurious findings. (shrink)

Research on meditation and mindfulness practice has flourished in recent years. While much of this research has focused on well-being outcomes associated with mindfulness practice, less research has focused on how perception of self may change as a result of mindfulness practice, or whether these changes in self-perception may be mechanisms of mindfulness in action. This is somewhat surprising given that mindfulness derives from traditions often described as guiding people to realise and experience the non-separation of self from the world (...) or its ‘oneness’ with the whole of reality. The current study used a collective intelligence methodology, Interactive Management (IM), to explore the nature of oneness experiences. Five IM sessions were conducted with five separate groups of experienced meditators. Participants generated, clarified, and selected oneness self-perceptions they believed most characterised their experience both during meditation and in their everyday experience in the world. Each group also developed structural models describing how highly ranked aspects of oneness self-perceptions are interrelated in a system. Consistent themes and categories of oneness experience appeared across the five IM sessions, with changes in the sense of space (unboundedness), time, identity, wholeness and flow highlighted as most influential. Results are discussed in light of emerging theory and research on oneness self-perception and non-dual awareness. (shrink)

David Chalmers' dancing qualia argument is intended to show that phenomenal experiences, or qualia, are organizational invariants. The dancing qualia argument is a reductio ad absurdum, attempting to demonstrate that holding an alternative position, such as the famous inverted spectrum argument, leads one to an implausible position about the relation between consciousness and cognition. In this paper, we argue that Chalmers' dancing qualia argument fails to establish the plausibility of qualia being organizational invariants. Even stronger, we will argue that the (...) gap in the argument cannot be closed. (shrink)

O'Brien & Opie run into conceptual problems trying to equate stable patterns of neural activation with phenomenal experiences. They also seem to make a logical mistake in thinking that the brute association between stable neural patterns and phenomenal experiences implies that they are identical. In general, the authors do not provide us with a story as to why stable neural patterns constitute phenomenal experience.

Games, Norms, and Reasons: Logic at the Crossroads provides an overview of modern logic focusing on its relationships with other disciplines, including new interfaces with rational choice theory, epistemology, game theory and informatics. This book continues a series called "Logic at the Crossroads" whose title reflects a view that the deep insights from the classical phase of mathematical logic can form a harmonious mixture with a new, more ambitious research agenda of understanding and enhancing human reasoning and intelligent interaction. The (...) editors have gathered together articles from active authors in this new area that explore dynamic logical aspects of norms, reasons, preferences and beliefs in human agency, human interaction and groups. The book pays a special tribute to Professor Rohit Parikh, a pioneer in this movement. (shrink)

We investigated whether regret predicted the motivation to act heroically. In a series of studies, we examined the relationship between regret, search for meaning in life, and heroism motivation. First, Study 1 (a and b) established the link between regret and search for meaning in life, considering regret as a whole, action regret, and inaction regret. Specifically, regret correlated positively with search for meaning in life. In additional two studies, we examined whether regret predicted the heroism motivation and whether this (...) effect would be mediated through search for meaning in life. Study 2 confirmed this hypothesis for individual differences in regret, using a correlational design. Study 3 confirmed the hypothesis for temporary experiences of regret, using an experimental design. In addition, in Study 3 we found that heroism motivation was more likely for people with high self-enhancement needs than for those with lower self-enhancement needs. We discuss the relationship between regret and heroism in light of these results and explore implications for everyday life. (shrink)

Unfair offers in bargaining may have disruptive effects because they may reduce interpersonal trust. In such situations future trust may be strongly affected by social accounts (i.e., apologies vs. denials). In the current paper we investigate when people are most likely to demand social accounts for the unfair offer (Experiment 1), and when social accounts will have the highest impact (Experiment 2). We hypothesized that the need for and impact of social accounts will be highest when the intentions of the (...) other party are uncertain. The results provided support for this reasoning. (shrink)

Disillusionment is acknowledged to be a painful process with important personal and social consequences. However, scientific conceptualisations of the experience are inconsistent. Across four studies, we examined whether lay conceptions of disillusionment produce a consistent pattern of features. In Study 1 (N = 204), we extracted 19 features of disillusionment from open-ended participant definitions. In Study 2 (N = 131), participants rated the centrality of these features and indicated that features such as discovery, disappointment, and loss, were highly representative, while (...) features such as hopelessness, orientation, and truth, were more peripheral. In two further studies, we used experimental designs to test the diagnosticity of these features. In Study 3 (N = 155), participants rated vignettes descriptions as more disillusioning when they were based on more, rather than less, prototypical disillusionment features. Given that disappointment is a feature of disillusionment, we conducted Study 4 (N = 60) to test whether the extracted features effectively distinguish disillusionment from disappointment. Overall, we found evidence to suggest that disillusionment contains a consistent set of features, and represents a state of negative epistemic affect associated with the violation of core assumptions. These results create avenues for research on disillusionment, its antecedents and its consequences. (shrink)

This book surveys and examines the most famous philosophical arguments against building a machine with human-level intelligence. From claims and counter-claims about the ability to implement consciousness, rationality, and meaning, to arguments about cognitive architecture, the book presents a vivid history of the clash between the philosophy and AI. Tellingly, the AI Wars are mostly quiet now. Explaining this crucial fact opens new paths to understanding the current resurgence AI (especially, deep learning AI and robotics), what happens when philosophy meets (...) science, and the role of philosophy in the culture in which it is embedded. -/- Organising the arguments into four core topics - 'Is AI possible', 'Architectures of the Mind', 'Mental Semantics and Mental Symbols' and 'Rationality and Creativity' - this book shows the debate that played out between the philosophers on both sides of the question, and, as well, the debate between philosophers and AI scientists and engineers building AI systems. Up-to-date and forward-looking, the book is packed with fresh insights and supporting material, including: -/- - Accessible introductions to each war, explaining the background behind the main arguments against AI - Each chapter details what happened in the AI wars, the legacy of the attacks, and what new controversies are on the horizon. - Extensive bibliography of key readings. (shrink)